Functional defects of fowl plague virus temperature-sensitive mutant having mutation in the neuraminidase
Identifieur interne : 002618 ( Main/Exploration ); précédent : 002617; suivant : 002619Functional defects of fowl plague virus temperature-sensitive mutant having mutation in the neuraminidase
Auteurs : Y. Ghendon [Russie] ; S. Markushin [Russie] ; V. Ginzburg [Russie] ; A. Hay [Royaume-Uni]Source :
- Archives of Virology [ 0304-8608 ] ; 1983-03-01.
English descriptors
- Teeft :
- Acta virol, Active haemagglutinin, Cell membranes, Cleavage, Crna, Fowl, Fowl plague virus, Gene coding, Haemagglutinin, Hours postinfection, Human influenza virus, Influenza, Influenza virus, Influenza virus genome, Mutant, Mutation, Neuraminidase, Neuraminidase activity, Poly, Polypeptide, Recombinant, Replication, Reproduction cycle, Rostock strain, Secondary transcription, Virion, Virol, Virology, Virus, Vrna, Weybridge strain.
Abstract
Summary: A fowl plague virus (FPV) temperature-sensitive mutantts 5 having mutation lesions in the gene coding for the neuraminidase has been obtained. The mutant induced synthesis of cRNA, vRNA and proteins in cells under non-permissive conditions, but formation of virions including non-infectious ones was defective. The neuraminidase and haemagglutinin synthesized under non-permissive conditions possessed functional activity and could migrate from the rough endoplasmic reticulum into plasma membranes; however, cleavage of the haem-agglutinin was reduced. Ints 5-infected cells under non-permissive conditions the synthesis of segments 5 and 8 of cRNA and vRNA was predominant both early and late in the reproduction cycle, and the synthesis of P1, P2, P3, HA and M proteins was reduced after approximately 3 hours. The data obtained suggest that involvement of the neuraminidase in the formation of infectious virions may have no direct association with the enzymatic activity of this protein, and that the mutation in the neuraminidase may affect regulation of replication and transcription processes.
Url:
DOI: 10.1007/BF01314127
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Summary: A fowl plague virus (FPV) temperature-sensitive mutantts 5 having mutation lesions in the gene coding for the neuraminidase has been obtained. The mutant induced synthesis of cRNA, vRNA and proteins in cells under non-permissive conditions, but formation of virions including non-infectious ones was defective. The neuraminidase and haemagglutinin synthesized under non-permissive conditions possessed functional activity and could migrate from the rough endoplasmic reticulum into plasma membranes; however, cleavage of the haem-agglutinin was reduced. Ints 5-infected cells under non-permissive conditions the synthesis of segments 5 and 8 of cRNA and vRNA was predominant both early and late in the reproduction cycle, and the synthesis of P1, P2, P3, HA and M proteins was reduced after approximately 3 hours. The data obtained suggest that involvement of the neuraminidase in the formation of infectious virions may have no direct association with the enzymatic activity of this protein, and that the mutation in the neuraminidase may affect regulation of replication and transcription processes.</div>
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